Adrenocortical Carcinoma: Basic Science and Clinical Concepts

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Use our advanced clinical trial search to find NCI-supported cancer clinical trials that are now enrolling patients. The search can be narrowed by location of the trial, type of treatment, name of the drug, and other criteria. General information about clinical trials is also available. Two other cytotoxic chemotherapy regimens are suggested to be effective and have been compared in a phase III trial:[ 2 ]. Furthermore, a substantial number of treated patients with functioning tumors will show diminution in hormone production.

In cases of increased hormone production, antisteroidogenic drugs such as ketoconazole and metyrapone, and steroid receptor antagonists, such as spironolactone and mifepristone, should be considered. The role of mitotane as adjuvant therapy after complete tumor resection is still a matter of debate but should be discussed with the patient. In the case of complete resection, the role for adjuvant mitotane and radiation therapy is the same as for stage I and stage II ACC.

Temporary palliation of disseminated adrenocortical carcinomas ACCs can sometimes be achieved with the chemotherapeutic agent mitotane.

ADRENOCORTICAL CARCINOMA‚ Basic Science and Clinical Concepts

Prolonged treatment with mitotane, however, is often limited by gastrointestinal and neurologic toxicity. Local recurrences and selected sites of metastatic disease can sometimes be palliated surgically or with radiation therapy.


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Two other cytotoxic chemotherapy regimens are suggested to be effective and have been compared in a phase III trial:[ 1 ]. In cases of increased hormone production, antisteroidogenic drugs, such as ketoconazole and metyrapone, and steroid receptor antagonists, such as spironolactone and mifepristone, should be considered. Clinical trials are appropriate and should be considered whenever possible because phase I and II trials evaluate newer chemotherapeutic and biologic agents.

The question of whether to further treat patients with adrenocortical carcinoma ACC , and the selection of treatment to use, depends on many factors, including previous treatment and site of recurrence as well as individual patient considerations. Local recurrence and selected sites of metastatic disease can sometimes be palliated by surgery or radiation therapy. Although patients with recurrent ACC cannot be considered curable, palliation of hormonal symptoms and occasional 5-year survivals can be achieved. Clinical trials are appropriate and should be considered whenever possible because phase I and II trials evaluate newer chemotherapeutic and biological agents.

The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above. This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about the treatment of adrenocortical carcinoma. It is intended as a resource to inform and assist clinicians who care for cancer patients.

It does not provide formal guidelines or recommendations for making health care decisions. Board members review recently published articles each month to determine whether an article should:. Changes to the summaries are made through a consensus process in which Board members evaluate the strength of the evidence in the published articles and determine how the article should be included in the summary. Any comments or questions about the summary content should be submitted to Cancer.

Do not contact the individual Board Members with questions or comments about the summaries. Board members will not respond to individual inquiries. Some of the reference citations in this summary are accompanied by a level-of-evidence designation. These designations are intended to help readers assess the strength of the evidence supporting the use of specific interventions or approaches.

PDQ is a registered trademark. Although the content of PDQ documents can be used freely as text, it cannot be identified as an NCI PDQ cancer information summary unless it is presented in its entirety and is regularly updated.

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However, an author would be permitted to write a sentence such as "NCI's PDQ cancer information summary about breast cancer prevention states the risks succinctly: [include excerpt from the summary]. Permission to use images outside the context of PDQ information must be obtained from the owner s and cannot be granted by the National Cancer Institute.

Information about using the illustrations in this summary, along with many other cancer-related images, is available in Visuals Online, a collection of over 2, scientific images. Based on the strength of the available evidence, treatment options may be described as either "standard" or "under clinical evaluation. More information on insurance coverage is available on Cancer. More information about contacting us or receiving help with the Cancer. Questions can also be submitted to Cancer. This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information.

Your use of this information means that you agree to the Terms of Use and Privacy Policy. Learn how we develop our content. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated. Skip to content. Health Library. Search Health Library. Prognostic Factors Retrospective studies have identified the following three important prognostic factors:[ 3 ] Completeness of resection. Stage of disease. Pathological grade. Diagnosis Initial evaluation should include careful endocrine studies to reveal any excessive hormone production by the tumor, which can serve as a tumor marker during therapy.

Prognosis and Survival The most common sites of metastases are the lung, liver, peritoneum, and less commonly, the bones and major veins. Cancer 11 : , Fassnacht M, Allolio B: Epidemiology of adrenocortical carcinoma. New York, Springer, , pp Langenbecks Arch Surg 7 : , J Clin Endocrinol Metab 91 6 : , Cellular Classification of Adrenocortical Carcinoma Adrenocortical carcinoma ACC can be classified into functioning and nonfunctioning tumors by clinical and biochemical assessment.

Precocious puberty. The differentiation of benign and malignant adrenocortical tumors can be achieved by determination of the Weiss score, which scores several histopathological criteria, including the following:[ 2 ] Nuclear grade. Number of mitoses. Presence of atypical mitosis. Percentage of clear cells. Diffuse architecture. Venous invasion. Sinusoidal invasion. Capsular invasion. Am J Surg Pathol 13 3 : , Here, Elizabeth Radford explores the extent to which epigenetic inheritance Interventions in endocrinology make a huge impact on life of patients with endocrine diseases.

Effective problem solving, decision-making, interpersonal, and teamwork skills. We publish polished, concise, highly read and cited articles of topics at the cutting edge covering basic, translational, and clinical aspects; from state-of-the-art treatments of endocrine diseases to new developments in molecular biology. The journal aims to provide a widely available resource for people working within the field of diabetes and endocrinology, in order to improve the care of people affected by these conditions.


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Panja believes that health care is a partnership in which the patient is actively included in decision making, treatment planning and follow-up care. Series of Endocrinology, Diabetes and Metabolism aims to publish the most recent and updated researches. The journal is an open access publication covering significant research works related to Endocrinology, Type 1 Diabetes, Type 2 Diabetes, Monogenic Diabetes, Gestational Diabetes and Cystic Fibrosis-related Diabetes and lot more.

International Adrenal Cancer Symposium

This document represents the official position of the American Association of Clinical Endocrinologists and the American College of Endocrinology. Endocrinology is a branch of medicine that concerns the study of hormones and its disorders. He has been in practice since The scope encompasses all subjects related to biochemical and molecular aspects of endocrine research and cell regulation. Effective verbal and written communication skills. Intrauterine death following intraamniotic triiodothyronine and thyroxine therapy for fetal goitrous hypothyroidism associated with polyhydramnios and caused by a About PREP Endocrinology.

The Division of Endocrinology is engaged in research on a variety of glandular and metabolic conditions, including diabetes and complications of diabetes, thyroid and parathyroid disease, pituitary disease, adrenal disease and more. The journal publishes on topics covering gametogenesis, fertilization, early embryonic development, embryo-uterus interaction, reproductive development, pregnancy, uterine biology, endocrinology of reproduction, control of reproduction, reproductive Scope.

Cellular Classification of Adrenocortical Carcinoma

Journal of Molecular Endocrinology is a leading global journal that publishes original research articles and reviews. Requested Verified P The journal publishes on topics covering gametogenesis, fertilization, early embryonic development, embryo-uterus interaction, reproductive development, pregnancy, uterine biology, endocrinology of reproduction, control of reproduction, reproductive International Journal of Clinical Endocrinology and Metabolism is an Open Access peer reviewed, online publishing journal, which aims to publish quality papers in the relevant areas of current advanced research.

The American Academy of Nurse Practitioners says NPs are independent practitioners certified to diagnose and treat acute and chronic conditions such as diabetes, high blood pressure, infections, and injuries.

Ancillary topics such as metabolism and diabetic complications are also covered under the scope of these Journals. Journal of Endocrinology and Diabetes Mellitus is an international peer reviewed journal which considers manuscript on diabetes and all other disorder of endocrine system in addition to related genetics, pathophysiological and epidemiological topics. While the global epidemic of type 2 diabetes T2D continues to be a major focus of clinical research, the journal also reflects the scope of the broadening discipline of endocrinology.

It speaks very highly of the organizers of this meeting as it is no small task to get medical researchers from around the world to gather at a single site for an exchange of ideas.

Our research faculty are all successful investigators in their own right but also cooperate closely with other investigators in both basic and clinical departments to pursue interdisciplinary Current knowledge of the nursing role and scope of practice as defined by the State of Ohio Nurse Practice Act and the Ohio Board of Nursing. Aims and scope Domestic Animal Endocrinology publishes scientific papers dealing with fundamental, translational, and clinical aspects of the endocrinology of domestic animal species at all levels of organization organismal, cellular, and molecular.

Endocrinology Research and Metabolism is a new online, international, open access, peer-reviewed, scientific journal dedicated to publish original articles, review articles, mini-reviews, case reports, short communications, commentaries, etc. By closing this message, you are consenting to our use of cookies.

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